yeah it means the site is taking ages to render on your connection, nothing major really
Again I cant replicate and I havent been able to trace, it has to be to do with your connection.
Basically the first time the 45.6079 seconds is how long it took to render the information and present it to you.
generally if there is a problem it is to do with queries. but for the queries to run to the database in less than a fraction of a second, indicates the site is running fine.
Basically the problem is either to do with how your ISP transports the data to your screen but in most likely hood it is something to do with how your computer reads and renders HTML. upgrade browsers and tone down the security a bit bro